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| the_mushroom_captivating_wartime_ukraine [2026/02/24 11:28] – created otiliathiessen0 | the_mushroom_captivating_wartime_ukraine [2026/02/25 12:05] (current) – created rachaeledye |
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| But by the time I was able to tag along on one of his foraging trips in October, he had moved to southern Poland, fearful for his and his family’s safety after a barrage of Russian missile attacks hit western Ukraine in late 2024. At the time, Hordubei was living south of the city of Lviv in western Ukraine, on the edge of the Carpathian Mountains. I wanted to understand what it meant to look for amanita in the wild, not just as an economic activity, but as a cultural practice. It may have started that way, as a source of supplemental food during times of scarcity and famine. She also started using amanita during the war and found that it helped her sleep — and gain a new appreciation for nature while living in an urban setting. Although the store only began selling amanita a few months earlier, Alexandra said the war coincided with a growing interest in microdosing for general wellness, as the psychedelic renaissance spread to Ukrain | We tease her very fun book, Psychedelics A to Z, which provides an in-depth, illustrated guide through the world of psychedelics, from the science behind them to their therapeutic potential, and everything in betwee |
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| | "Our results revealed that when a volunteer was on DMT there was a marked dysregulation of some of the brain rhythms that would ordinarily be dominant. The brain switched in its mode of functioning to something altogether more anarchi |
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| Participants gave written informed consent and received standard monetary compensation for their participation in the study. Participants using antidepressants or other psychoactive compounds at screening followed a tapering off and washout procedure prior to study entrance. The study was approved by the Dutch Central Committee on Research Involving Human Subjects (CCMO) and the Medical Ethics Committee of the Academic Hospital of Maastricht and Maastricht University and conducted according to the principles of Good Clinical Practice (GCP) and the code of ethics on human experimentation established by the declaration of Helsinki (1964) and amended in Fortaleza (2013). The study was conducted at the Faculty of Psychology and Neuroscience, Maastricht University, The Netherlands. In the GH001 program, preparation and support is provided as part of standard medical care, and consists of standard informed consent, provision of a comfortable dosing environment, and availability of medical and psychological support throughout the stud | |
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| Electrophysiological effects of 5-MeO-DMT | Save my name, email, and website in this browser for the next time I comment. Our commitment to quality, secure shipping, and professional support ensures that you can conduct your studies safely and efficiently. Its distinct profile allows researchers to investigate brain function, receptor activity, and potential therapeutic mechanisms safely under lab conditions. While chemically related to DMT, it produces distinct effects and a shorter duration, making it a valuable compound for laboratory studies. |
| DOI also led to a decrease in prefrontal cortical slow oscillations in anaesthetised animals, possibly decreasing global synchronisation21. More recently, the electrophysiological dynamics that underlie acute psychedelic experiences have begun to be investigated in rodents. State map analysis of the spectral profile of waking behaviour induced by 5-MeO-DMT revealed similarities to electrophysiological states observed during slow-wave sleep (SWS) and rapid-eye-movement (REM) sleep. | Journali |
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| In addition, DMT is a potent serotonin releasing agent with an EC50Tooltip half-maximal effective concentration value of 81–114 nM and an EmaxTooltip maximal efficacy of 78%. DMT inhibited SERT-mediated serotonin uptake into platelets at an average concentration of 4.00 ± 0.70 μmol/L and VMAT2-mediated serotonin uptake at an average concentration of 93 ± 6.8 μmol/L. It has also been shown in vitro to be a substrate for the cell-surface serotonin transporter (SERT) expressed in human platelets, and the rat vesicular monoamine transporter 2 (VMAT2), which was transiently expressed in fall armyworm Sf9 cells. This may be of importance because chronic or frequent uses of serotonergic drugs showing preferential high affinity and clear agonism at 5-HT2B receptor have been causally linked to valvular heart diseas | In accordance with the preceding findings, 5-MeO-DMT is reported to produce notably distinct subjective effects compared to DMT and other psychedelics in humans. In contrast to most serotonergic psychedelics however, it has been said that it is unclear that the hallucinogenic effects of 5-MeO-DMT are principally mediated by activation of the serotonin 5-HT2A receptor. While most common psychedelics are believed to primarily elicit psychological effects through agonism of serotonin 5-HT2A receptors, 5-MeO-DMT shows 1,000-fold greater affinity for the serotonin 5-HT1A receptor over the serotonin 5-HT2A receptor. As with DMT and other psychedelics, the experiences with 5-MeO-DMT are often described as overwhelming, profound, spiritual, religious, and/or mystical. Another psychedelic tryptamine that produced similar effects to 5-MeO-DMT was 5-MeO-MiPT at sufficiently high doses smoked. In the case of an unspecified large overdose smoked, the person lapsed into a coma-like state, their face turned purple, they stopped breathing and had to be resuscitated multiple times, and they experienced a several-day psychosis necessitating antipsychotic |
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| 5-MeO-DMT can cause loss of consciousness, which may lead to bodily injury or even asphyxiation which can result in death. Preparation is what will allow you to make the most of your experience. Preparation is a crucial part of any 5-MeO-DMT experience. If you know others who have worked with this molecule, check in with them about their experience. Read everything you can about this molecule - its history, how and why people use it, how to prepare for it, how to integrate it, and the types of adverse events that people experience. | |
| Introduction and Rationale for Study | |
| Other 5-methoxytryptamines like 5-MeO-DET and 5-MeO-DPT were plagued by dose-limiting side effects that resulted in Shulgin having an unfavorable impression of them, whereas 5-MeO-DiPT and 5-MeO-DALT produced only light psychedelic effects. [[https://buylsdonline.io/de-de/product/5-meo-dmt-pulver/|5-MeO-DMT]] was one of the only psychedelics in TiHKAL that resulted in a plus-four experience on the Shulgin Rating Scale. With harmaline doses of 70 to 150 mg orally, 5-MeO-DMT becomes orally active at doses of 10 to 25 mg, the onset is 15 to 18 minutes, peak effects occur after 1.5 hours, and the duration is at least 3 or 4 hours. Use of 5-MeO-DMT is rare compared with other psychedelics, with only 0.003% of the United States general population having reported taking it in 2019 (compared to 8.5% for psilocybin | |
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| Cocaine. Cocaine is a white powdery drug which is an addictive stimulant. It increases dopamine levels, leading to euphoria and heightened energy. Cocaine is also manufactured in a rock form called crack cocaine which creates an intense high that kicks in faste | When taken intravenously, DMT is primarily metabolized MAO-A in the circulatory system and brain. Studies on the llipophilicity of DMT have been contradictory – most studies find DMT to be either lipophilic or slightly lipophilic, but a 2023 study found it to be lipophobic. Similar active transport and accumulation processes likely occur in human brains and may concentrate DMT in brain by several-fold or more (relatively to blood), resulting in local 5-meo-dmt concentrations in the micromolar or higher range. However, several studies have described active transport and accumulation of DMT into rat and dog brains following peripheral administration. In September 2020, an in vitro and in vivo study found that DMT present in the ayahuasca infusion promotes neurogenesis, meaning it helps with generating neurons. |
| | This is congruent with the previous study where 5-MeO-DMT-induced mystical experiences comparable to those after 30 mg psilocybin6. Like psilocybin, LSD, and N,N-DMT, it can induce profound alterations in consciousness, mystical experiences, ego dissolution, emotional breakthroughs and cathartic experiences, and feelings of insight and connection. It is important to note that psychedelic experiences can be neither transcendental nor particularly challenging or insightful. This is similar to previous clinical trials with psychedelics, where trust and relationship with psychedelic therapists/monitors are named as highly important15,46. Remembering the preparation sessions, as well as presence and/or therapeutic touch from the psychedelic monitor helped participants relax into the experienc |
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| | One side feared IIT’s reputation would drag consciousness science even further toward the fringes, and the other worried that publicly tarring one theory with a "pseudoscience" label would lead to the downfall of the entire 5-meo-dmt field. The prospect that the field could lose its legitimacy hung over the fight. GNWT also predicts that this ignition signal will appear as two discrete spikes of activity—one when an image is first presented and one when it’s removed—whereas IIT predicts sustained activity as long as a person is looking at an image. Researchers developed predictions from each theory about what should happen in the brain when an image is consciously perceived versus when it’s no |
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| | Percentage of state duration (left panel) and mean speed (right panel) of each sleep-waking state for saline and different doses of 5-MeO-DMT experiments (ANOVA, #p p Full size imageNext, we computed the duration and animal speed (locomotion) for each sleep or wake episod |
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| | In summary, our findings indicate that 5-MeO-DMT administration leads to a decrease in theta power in the hippocampus for equivalent locomotion speeds, as well as an increase in delta power specifically following IP injections. As the drug significantly affected locomotion (Fig. 1B) and speed is known to influence LFPs, we employed a generalised linear model (GLM) to assess the effect of 5-MeO-DMT administration on delta (1–4 Hz) and theta (5–12 Hz) power while accounting for speed (Fig. 2, see Methods for details). Percentage of state duration (left panel) and mean speed (right panel) of each sleep-waking state for saline and different doses of [[https://buylsdonline.io/fr/product/5-meo-dmt/|5-MeO-DMT]] experiments (ANOVA, #p p Full size imageNext, we computed the duration and animal speed (locomotion) for each sleep or wake episode. Notice the decrease in theta normalised power after 5-MeO-DMT in comparison to saline dosing.Full size imageTo analyse the spectral patterns of 1-s windows of combined hippocampal and cortical activity, we used a manifold approach called state map3 |
