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| MDMA is reported in small numbers of drug-induced deaths, and in most countries less than 1 in 20 cases involve the drug. While affected by limitations and uncertainties, this type of data analysis shows great promise as a complementary information source to monitor the size and changes in drug markets (Quireyns et al., 2023). It was possible to construct estimates of city-level MDMA market sizes by combining wastewater data with country-level data for average retail purity and price. Demand-based estimates may underestimate the size of drug markets for a number of reasons, including difficulty reaching some groups of users, and underreporting of prevalence and quantities used by respondents. Estimates of amounts used suggest that about 72.4 million ecstasy tablets were consumed in the European Union in 2021. In the case of Belgium, Czechia, France, Luxembourg, Malta, Norway and Portugal, no recent data for last month prevalence of MDMA were reported, so data were impute | The share of acute drug-toxicity presentations involving MDMA increased as compared to other substances and the previous year (or MDMA was reported for the first time) in 10 of the Euro-DEN hospitals. When using wastewater data to estimate MDMA markets, the use of MDMA is based on the excreted parent drug, rather than on an excreted metabolite (which is the case for some other drugs, such as cocaine and heroin). Demand-based estimates may underestimate the size of drug markets for a number of reasons, including difficulty reaching some groups of users, and underreporting of prevalence and quantities used by respondents. Estimates of amounts used suggest that about 72.4 million ecstasy tablets were consumed in the European Union in 2021. The total quantity of MDMA consumed in Europe is reached by multiplying the number of users by the amount used, combining prevalence data from general population surveys and the amount used from the EWSD. Information gathered in the 2021 EWSD suggests that, on average, those who reported having used MDMA in the last 12 months, consumed one ecstasy tablet or 0.4 grams of MDMA in crystal or powders form each time they used the drug. |
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| Surrey Young People’s Substance Use Service | Surrey Young People’s Substance Use Service |
| City-level market size estimates were developed for Brussels, in Belgium, and five cities in Sweden (see Table 6.1. Estimated value of MDMA consumed in selected European cities, 2020). The price data used was the average retail price for MDMA in the country concerned, drawn from the EUDA’s annual data collection (see Section Price and purity). For some countries (Belgium, Croatia, Denmark, France, Malta, Netherlands, Norway and Türkiye) no data were available from the EWSD. The annual amounts used, in tablets, could be estimated for each survey participant based on their responses to questions on the number of tablets used on a typical day, multiplied by the number of days they said they used the drug in a year. As such, only last year prevalence and last month [[https://royalmedspharma.com/ultimate-guide-to-spotting-pretend-and-harmful-ecstasy-pills-for-public-safety/|royalmedspharma.com]] prevalence data are required to distinguish these two groups. Prevalence rates of the number of MDMA users, obtained from general population surveys, are multiplied by 2021 Eurostat population data of the age group. | Since most users take this drug only occasionally, dependence is not very prominent. Although some users become dependent, very few cases of MDMA-specific dependence have been reported in the literature. That said, with repeated use, it becomes difficult, if not impossible for users to experience the same effects they did when they first started. The significant [[https://royalmedspharma.com/mdma-legality-standing-by-country/|buy mdma]] increase in serotonin and dopamine during MDMA use can result in users seeking these feelings repeatedly, leading to habitual use and eventually, dependency. The addiction risk ties back to its effects on neurotransmitters. They can lead to extended wakefulness and increased physical activity, which can strain the user’s cardiovascular system and overall physical health. |
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| While a slight decrease in price was observed in 2022 for ecstasy tablets, this may not be statistically significant or sustained in the coming years. In fact, it could be argued that MDMA in the form of ecstasy tablets became cheaper between 2012 and 2019 as tablets containing larger quantities of MDMA became increasingly available on the market (see Section The trend of large tablets containing more MDMA may be reversing). For countries reporting data in 2022, a considerable retail price range was observed, with prices per ecstasy tablet ranging from EUR 4 to EUR 19 (mean) and prices of MDMA powder from EUR 6 to EUR 50 per gram. Occasionally, tablets containing 250 milligrams or more of MDMA are encountered on EU drug markets. This trend may be a combination of the scheduling of PMK glycidate, and a reduction in demand for MDMA during the COVID-19 pandemic, and is in line with the changes observed in the adulteration of ecstasy tablets (see Section Ecstasy adulteration is responsive to market pressures). This means that the ratio of MDMA to fillers (excipients) in the mixtures used to make ecstasy tablets did not increase over this time period. | |
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| The majority of drug-induced deaths in Türkiye are among younger people, predominantly males, and are more likely to involve stimulant drugs rather than opioids, compared with the European Union and Norway. For example, in Germany, MDMA was mentioned in 1 in 25 fatal overdoses in 2022, with most of the cases involving multiple drugs. A review of MDMA-related mortality in royalmedspharma.com Australia and three European countries (Portugal, Finland and Türkiye) showed an increase in the number of fatalities between 2011 and 2017 (Roxburgh et al., 2021). However, studies have suggested that an increase has been observed in some countries. Furthermore, when factoring in the higher price of MDMA in Sweden, the market value in Stockholm is about 3.5 times that of Brussels. | Estimates from darknet market studies in 2015 suggested that MDMA was the third most popular drug (after cannabis and pharmaceuticals) purchased on the darknet, accounting for 25% of drug sales. MDMA has also developed a substantial niche in online darknet markets accessed via dedicated TOR browsers and paid for using cryptocurrencies like Bitcoin. The addiction risk ties back to its effects on neurotransmitters. MDMA, due to its psychoactive effects and potential for misuse, is a substance often tested for in various drug screening processes. When sold in pill form, two pills with the same logo or symbol may have different effects — they can come from different sources and have different ingredient |
| Ecstasy adulteration is responsive to market pressures | |
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| It’s important to be careful when taking any type of drug. This makes it hard to know what reactions to expect after taking MDMA or if negative side effects will be experienced. RAND is a research organization that develops solutions to public policy challenges to help make communities throughout the world safer and more secure, healthier and more prosperous. In essence, cryptomarkets have grown at a fairly decent rate since 2013, but their global impact could be overstated — for now. The specialization also reflects the interconnection of physical and virtual drug distribution channel | For some countries (Belgium, Croatia, Denmark, France, Malta, Netherlands, Norway and Türkiye) no data were available from the EWSD. The annual amounts used, in tablets, could be estimated for each survey participant based on their responses to questions on the number of tablets used on a typical day, multiplied by the number of days they said they used the drug in a year. As such, only last year prevalence and last month prevalence data are required to distinguish these two groups. Prevalence rates of the number of MDMA users, obtained from general population surveys, are multiplied by 2021 Eurostat population data of the age group. Wastewater data also reflect the predominant use of ecstasy in recreational settings, with more than three quarters of cities reporting that higher loads of MDMA were present in wastewater during the weekend than during weekdays in 2022. While the number of tablets used per session has not changed substantially from literature findings dating from several decades ago, today’s MDMA users generally ingest higher quantities of the psychoactive substance than before (Gremeaux, 2022 |
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| The total quantity of MDMA consumed in Europe is reached by multiplying the number of users by the amount used, combining prevalence data from general population surveys and the amount used from the EWSD. | |
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| | Choosing 12 Panel Now provides customers with a comprehensive and cutting-edge solution for drug testing needs. Utilizing a MDMA Ecstasy/Molly Test is beneficial for employers and institutions aiming to maintain drug-free environments. While it is not as addictive as other substances like nicotine or opioids, repeated use can lead to dependency. They can lead to extended wakefulness and increased physical activity, which can strain the user’s cardiovascular system and overall physical health. Synonymous with the energetic boosts provided by other stimulants like caffeine or methamphetamines, MDMA’s stimulant effects can be intense. These psychedelic effects are generally subtler compared to other hallucinogens like LS |
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| This finding is interesting because it challenges the convention that cryptomarkets facilitate the globalization of drug retail markets. The most common routes for drugs were those within North America, Europe, and Oceania. We find that cryptomarkets still tend to be dominated by vendors from the US, the UK, Australia, and a few other countries (see figure below). Since Silk Road (the first cryptomarket) was put under the spotlight in 2011, the role these online market places play in global illegal trade has become hotly debated. In the worst cases, a fake pill may contain drugs or chemicals that could harm you. Medicines sold online and by places that do not have a physical address can be fak | According to 2021 data, tablets and powders/crystals share the EU MDMA market equally, with some variability among countries in terms of preference for either ecstasy tablets or MDMA powders/crystals (see Figure 6.1. Distribution of usual MDMA forms across countries |
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| | Where prevalence is higher, it may suggest that MDMA is no longer a niche or subcultural drug limited to dance clubs and parties in those markets. According to survey data, the two largest MDMA consumer markets per capita in the European Union are the Netherlands and Ireland, with 6 % or more buy mdma people aged 15 to 34 reporting to have consumed MDMA in the last year. Some of the high-strength ecstasy tablets are scored to allow consumers to divide them into smaller portions. |
