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| BONUS 007 Anatha Fest BTS: The Tea on 2024 + My Experience in 2025 as an Artist & Vendor | A higher concentration of power within the theta range of the triggered envelopes indicates a stronger modulation between the theta phase and the gamma amplitude.Figure 4Hippocampal theta-nested slow- and mid-gamma oscillations after 5-MeO-DM |
| "I think psychedelics are a gift of the gods," Feilding said, waving her hands about. What we now consider the psychedelic renaissance can be dated to around four or five years later, when the drugs began to show promise for treating addiction, depression, and other disorders. Modern therapeutic 5-meo-dmt applications typically involve careful preparation, professional supervision, and integration support - quite different from historical shamanic use | |
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| As a result, Strassman writes these experiences among his experimental participants "also left me feeling confused and concerned about where the spirit molecule was leading us. It was at this point that I began to wonder if I was getting in over my head with this research | As Cosmo put it when we spoke last year, "There’s a tension between the ideals that a psychedelic experience can engender in people versus the business of making drugs available in the real world." Even the pursuit of transcendence could be warped by the logic of profi |
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| Several U.S. states have approved psilocybin-containing "magic" mushrooms to treat depression, while retreats offering ayahuasca, a powerful psychedelic brew made from a South American vine, are becoming increasingly popular for traumatized populations such as military veteran | Psychedelics lead to profound changes in subjective experience and behaviour, which are typically conceptualised in psychological terms rather than corresponding to an altered brain state or a distinct state of vigilanc |
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| However, all of the users and six sellers I spoke to in Ukraine and the U.S. recommend microdosing, both for safety and because those large [[https://buylsdonline.io/da/product/5-meo-dmt/|5-meo-dmt]] doses don’t typically have any kind of therapeutic utility. Unlike psilocybin mushrooms, amanita has never been successfully cultivated in a lab and must be foraged from its native environment, where it grows in symbiosis with trees such as oaks, firs and birches. Several U.S. states have approved psilocybin-containing "magic" mushrooms to treat depression, while retreats offering ayahuasca, a powerful psychedelic brew made from a South American vine, are becoming increasingly popular for traumatized populations such as military veterans. Ukrainian doctors have warned people against using it, questioning its effectiveness and warning of its potentially toxic effects. "The whole country requires psychotherapy," said Tatiana Boichuk, a mushroom forager who has sold amanita to thousands of people across Ukraine over the past two years. In the last three years, foragers who collect amanita from forested mountainsides every fall and sell it as an herbal supplement have seen demand balloo | Recent research at Johns Hopkins (2019) shows it creates a rapid reset of brain connectivity patterns, particularly in areas linked to emotional processing and self-awareness (Source). Unlike common assumptions that it simply "gets you high," this compound creates profound neurological changes that can last weeks or months after a single dose. However, this is an extremely potent medicine demanding immense respect - roughly 4-6 times stronger than regular DMT. Many experience complete dissolution of ego boundaries, which some find deeply liberating while others find terrifying. These acute effects usually last minutes, though some people report lingering physical sensitivity for several hours afterwar |
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| Participants gave written informed consent and received standard monetary compensation for their participation in the study. Participants using antidepressants or other psychoactive compounds at screening followed a tapering off and washout procedure prior to study entrance. The study was approved by the Dutch Central Committee on Research Involving Human Subjects (CCMO) and the Medical Ethics Committee of the Academic Hospital of Maastricht and Maastricht University and conducted according to the principles of Good Clinical Practice (GCP) and the code of ethics on human experimentation established by the declaration of Helsinki (1964) and amended in Fortaleza (2013). The study was conducted at the Faculty of Psychology and Neuroscience, Maastricht University, The Netherlands. In the GH001 program, preparation and support is provided as part of standard medical care, and consists of standard informed consent, provision of a comfortable dosing environment, and availability of medical and psychological support throughout the stud | Cocaine. Cocaine is a white powdery drug which is an addictive stimulant. It increases dopamine levels, leading to euphoria and heightened energy. Cocaine is also manufactured in a rock form called crack cocaine which creates an intense high that kicks in faste |
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| A 2013 study found DMT in microdialysate obtained from a rat's pineal gland, providing evidence of endogenous DMT in the mammalian brain. In an article published four months later, the method used in their study was strongly criticized, and the credibility of their results challenged. These results show for the first time that the rat brain is capable of synthesizing and releasing DMT at concentrations comparable to known monoamine neurotransmitters and raise the possibility that this phenomenon may occur similarly in human brains. Additionally, extracellular concentrations of DMT in the cerebral cortex of normal behaving rats, with or without the pineal gland, were similar to those of canonical monoamine neurotransmitters including serotonin. N,N-Dimethyltryptamine (DMT), a psychedelic compound identified endogenously in mammals, is biosynthesized by aromatic L-amino acid decarboxylase (AADC) and indolethylamine-N-methyltransferase (INMT). This immunomodulatory activity may contribute to significant anti-inflammatory effects and tissue regeneratio | The IDR is enabled by the short half-life of GH001, by its short duration of psychoactive effects and by its lack of tachyphylaxis. In clinical trials, an inadequate therapeutic response to at least one pharmacotherapy, one pharmacotherapy and one psychotherapy, or two pharmacotherapies within the same depressive episode has been used (17). Further, antidepressant properties of other tryptamines such as psilocybin and DMT have been suggested in clinical populations in clinical trials (10–12). 5-MeO-DMT is a naturally-occurring substance, and it has a long history of use in naturalistic contexts, where its ability to induce altered states of consciousness (4, 6), often described as ego-dissolution and feelings of unity and connectedness with the universe, has been applied for spiritual or self-exploratory purposes (2, 7). Treatment-resistant depression (TRD) is a substantial public health burden, but current treatments have limited effectiveness. In terms of a scientific understanding, the hallucinogenic effects of DMT were not uncovered until 1956 by Hungarian chemist and psychiatrist Stephen Szára. |
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| | This was in contrast to previous research finding that SSRIs diminished the effects of serotonergic psychedelics. Repeated and one-time administration of DMT produces marked changes in the cardiovascular system, with an increase in systolic and diastolic blood pressure; although the changes were not statistically significant, a robust trend towards significance[clarification needed] was observed for systolic blood pressure at high doses. A fully hallucinogenic dose of DMT did not demonstrate cross-tolerance to human subjects who are highly tolerant to LSD; hence, research suggests that DMT exhibits unique pharmacological properties compared to other classical psychedelics. Unlike with other classical psychedelics, tolerance does not seem to develop to the subjective effects of DMT. |
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| Hordubei sells amanita to customers online and takes it himself, but unlike Soloshenko, he doesn’t credit the mushroom with any major life changes or shifts in his mental health. Another GABA mimic is alcohol, and users have described the effects of medium-to-high doses of amanita as similar to being inebriated. When eaten raw, large doses of amanita trigger a dreamlike, potentially frightening experience that lasts hours and can, on rare occasions, be deadl | |
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| | It is 5-meo-dmt often compared to DMT since both offer similar experiences, but [[http://bonecareusa.com/bbs/board.php?bo_table=free&wr_id=825976|5-MeO-DMT]] is stronger compared to DMT. The dosing experience interview part of the BPL-003–103 study was optional. By combining microphenomenology with neurophysiological measures, future work on the acute effects of 5-MeO-DMT could illuminate aspects of consciousness related to emotion, somatic sensations, and the sense of self. Challenging experiences, while difficult, also appeared to provide opportunities for emotional breakthroughs and insight |
| In dreamless sleep, this doesn’t happen, Massimini had previously found. In a conscious brain (whether awake or dreaming), the disturbance ripples outward as neurons cause neighbors in their networks to fire. "It’s like knocking on the brain directly," Massimini says, "to probe the internal structure." Then EEG measured brain waves to reveal how that stimulation spread. | |
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| Finally, the third factor measures ‘therapeutic response’, rated on a 5-point scale, anchored by ‘marked improvement and no side effects’ (0) and ‘unchanged or worse and side effects outweigh therapeutic effect’ (4). Regarding PCL-5 factors, she scored the highest on ‘altered reactivity’ (4.00 ± 0.00), followed by ‘thought intrusion’ (3.80 ± 0.45), ‘negative mood and cognitions’ (3.71 ± 0.49), and ‘stimuli 5-meo-dmt avoidance’ (3.50 ± 0.71). The ‘past week’ version of the PCL-5 was utilized in this case stud | |
